Cohort Study to eLucidAte Causes, Behaviour and Outcomes of gastRo Intestinal Tract Cancers in the Young

This prospective study is designed to establish a database of young adult patients diagnosed with gastro-intestinal malignancies, with availability of matched clinical data and biological samples including but not limited to tumour tissue. This will serve as a valuable platform to sub studies and collaboration with national and international groups, to better understand the pathogenesis of cancers in this unique cohort and to better tailor treatment to maximise efficacy and minimise toxicity. The analysis plan will develop as the study progresses. At the outset, three areas of interest for investigation are molecular profiling of the tumour and it's microenvironment, the intestinal microbiome and collaboration with groups developing patient derived organoids and metabolomics. It may also provide a platform for future longitudinal research to identify long term health trends.