Fuzhou Aging Brain Health Initiative

Alzheimer's disease (AD) represents a major public health challenge in China's aging society, and early screening and intervention are key to reducing the incidence of AD dementia. This project, in collaboration with multiple community health service centers in Fujian Province, China, aims to establish a retrospective and prospective, multi-center AD cohort. We plan to enroll approximately 3,000 elderly volunteers and collect comprehensive baseline and longitudinal follow-up data, including multi-dimensional digital-intelligence screening, plasma/cerebrospinal fluid biomarkers (Aβ42/Aβ40, p-Tau217, NfL, GFAP, sTREM2, etc.), APOE genotyping, electroencephalographic features, multi-modal MRI, and Aβ/tau PET imaging. All participants will undergo cognitive assessment, genetic screening, and blood sample collection. Some participants will also undergo cerebrospinal fluid (CSF) collection, electroencephalography (EEG), digital cognitive testing, MRI scans, Aβ PET scans, and tau PET scans. Annual follow-up will be conducted for all participants.