Inflammatory breast cancer is a rare and aggressive type of cancer where the tumor cells invade the lymphatic vessels in the skin. This causes the appearance of red and swollen breasts. Most participants are diagnosed with locally advanced disease, and the standard treatment is chemotherapy, followed by mastectomy and axillary lymph node dissection, radiation treatment, and then adjuvant therapy. But advances in therapy have called into question if mastectomy with ALND is still necessary in participants with IBC, with some physicians advocating for the option of sentinel lymph node biopsy. However, SLNB in participants with IBC has been met with mixed results.
Despite these mixed results, many physicians in the United Stares are still performing SLNB either using blue dyes or dual tracers. The purpose of this study is to find out the rate of identifying sentinel lymph nodes is participants with IBC , whether the sentinel lymph node status correlates with any more positive nodes, and the rates of complete response based on the subtype of IBC.
