Bronchoscopy diagnosis and treatment is highly irritating, and local topical anesthesia has poor effect; deep sedation or intravenous anesthesia based on topical anesthesia is currently recommended; COPD patients have impaired lung function, and bronchoscopy diagnosis and treatment is accompanied by significant peri-anesthetic risks of hypoxemia. COPD patients are prone to hypoxemia due to the shared airway and sedative and analgesic drugs used to suppress breathing during bronchoscopy diagnosis and treatment. Therefore, solving hypoxia is the biggest problem for COPD patients during anesthesia during bronchoscopy. In recent years, studies have found that high-flow nasal oxygen therapy (HFNC) can significantly reduce the incidence of hypoxemia during anesthesia during bronchoscopy. However, very few studies have performed HFNC on patients with COPD.