Pruritus that is chronic in duration (greater equal to 6 months)
Pruritus severity with a peak pruritus numerical rating score of ≥ 5 (moderate severity)
Model for End-Stage Liver Disease (MELD) score \< 15. This will capture patients with chronic stable liver disease without significant comorbid conditions and/or signs of rapidly progressive or decompensated liver failure
Willingness and ability to comply with scheduled clinic visits, physical exams, laboratory tests, questionnaires, effective contraception use, and other trial procedures
You may not be if
Pruritus due to a primary inflammatory skin dermatosis or other forms of psychogenic pruritus utilizing skin biopsies to exclude as needed
Pregnant females. Urine pregnancy test required at screening
History of intrahepatic cholestasis of pregnancy
Any form of chronic hepatic pruritus associated with underlying malignancy
Liver transplant recipients
Drug-induced liver pruritus
ALT or AST greater than 3 times the upper limit of normal or total bilirubin greater than 2 times upper normal limit
Advanced liver disease indicators including, ascites requiring therapeutic paracentesis, history of spontaneous bacterial peritonitis, any grade of hepatic encephalopathy, or a documented history of variceal bleeding within the preceding six months
