Age

18–75

Sex

ALL

Healthy volunteers

Not accepted

18-75 years of age
Willing and able to provide informed consent
Able to read and speak english
Opioid use disorder, in remission for at least a month
Diagnosis of major depressive disorder confirmed with the Mini-International Neuropsychiatric Interview (MINI, 7.02)
Minimum score of 10 on the 17-item Hamilton Depression Rating Scale (HDRS-17)
Opioid craving score of 5 or greater on a 0-10 scale
Stabilized on sublingual or depot buprenorphine for at least 8 weeks

Seizure disorder
any other acute medical or behavioral disorder that would preclude safe participation
Pregnant, nursing or planning to become pregnant during the study
Magnetic resonance imaging (MRI) contraindications, including ferrous retainers, intracranial implants, or claustrophobia
Surgical procedure planned during the study period
Any other medical condition that could compromise participant well-being

Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation