A Plant-Based Diet in the Treatment of Coronary Microvascular Dysfunction

You may be eligible if

• Women must be postmenopausal.
• History of angina, ischemic symptoms, or symptoms consistent with ischemia in the absence of obstructive coronary artery disease.
• No obstructive coronary artery disease (\<50% stenosis in any epicardial coronary artery or fractional flow reserve \>0.80).
• Clinically documented coronary microvascular dysfunction (CMD), including coronary flow reserve \<2.5 and/or index of microcirculatory resistance ≥25, or equivalent documentation in the medical record.
• Stable cardiometabolic medication regimen for at least 2 months before enrollment.
• Willingness to consume the study-provided plant-based diet and complete all study procedures.
• Ability to provide informed consent
• Exclusion:
• Obstructive coronary artery disease or prior coronary revascularization (PCI or CABG).
• Recent acute coronary syndrome, unstable angina, decompensated heart failure, or other clinically unstable cardiovascular disease.
• Significant structural heart disease, uncontrolled arrhythmia, severe uncontrolled hypertension, or symptomatic hypotension.
• Severe renal disease (eGFR \<30 mL/min/1.73 m²) or significant liver disease.
• Current vegetarian or vegan diet, or habitual consumption of ≤4 servings of animal products per week.
• Severe food allergies, dietary restrictions, or gastrointestinal conditions that would prevent adherence to the study diet.
• Current use of weight-loss medications, including GLP-1 receptor agonists.
• Active eating disorder.
• Recent (\>5%) intentional or unintentional weight change within the previous 3 months.
• Participation in another interventional study that could affect study outcomes.
• Any medical, psychiatric, or social condition that, in the investigator's judgment, would make participation unsafe or interfere with study completion.