Willing and able to provide written informed consent
Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV)
At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc).
The tumor(s) must be ≥1 cm in diameter
You may not be if
Participant is a candidate for upfront resection of pancreatic cancer
Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study
Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being
