Admitted to one of the following VUMC adult ICUs: Medical ICU, Pulmonary ICU
The participant or legally authorized representative must agree to the genetic analyses required as part of this study
You may not be if
Pregnant
Prisoner or in police custody
Patient desires comfort measures only or has a goals-of-care plan inconsistent with participation in non-beneficial research procedures
Hemoglobin less than 8 g/dL
Uncontrolled hyperglycemia (persistent blood glucose \>300 mg/dL) or any clinical condition in which additional IV glucose administration is not appropriate in the opinion of the Study Coordinator, PI, or treating ICU team
Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500 mL in an 8-week period
Unable to safely obtain vascular access required for study infusion and blood collection
Clinical instability or anticipated clinical care needs that would make the study procedure inappropriate at that time in the opinion of the Study Coordinator, PI, or treating ICU team
Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, might interfere with the study objectives
Any reason which, in the opinion of the study investigator, adds additional risk to the patient
