Patients with psychotic depression.

Patients already taking either of the trial drugs, based on the medical record.

Patients with substance use disorder or dependence within the previous 3 months.

Pregnant women, women planning to conceive within 3 months, or breastfeeding women.

Patients with another primary psychiatric disorder already receiving treatment.

Patients with a history of intolerance or allergy to minocycline or celecoxib.

Patients with active renal, hepatic, cardiac, or serious dermatological illness.

Patients receiving concomitant penicillin therapy or anticoagulants.

Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder