Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC

This is a single arm open label phase 2 clinical trial of a novel immunotherapy combination with Fc enhanced CTLA4 inhibitor, Vilastobart, in combination with PD-1 inhibitor, retifanlimab, in patients with metastatic pancreatic cancer who harbor a germline or somatic pathogenic alterations in BRCA1, BRCA2 or PALB2. The primary obejctive is to determine the efficacy of vilastobart in combination with retifanlimab in patients with BRCA1, BRCA2 or PALB2 altered pancreatic cancer as measured by objective response rate (ORR).This research study involves screening, study treatment with the study drugs, study visits, and follow-up visits. This study expects to enroll up to 40 participants. Participants will receive the study treatment for up to one year and will be followed for up to three years. The U.S. Food and Drug Administration (FDA) has not approved vilastobart as a treatment for any disease. The FDA has not approved retifanlimab (ZYNYZ) for this specific disease but it has been approved for other uses.