Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Adults (18 years and older).
Diagnosis of pancreatic cancer that cannot be removed by surgery or has spread to other parts of the body.
Cancer confirmed by tissue or cell examination (histology or cytology).
At least one measurable tumor on scans.
Good enough general health and organ function to receive study treatment, as judged by the study doctor.
Able to swallow oral medicines.
Willing to follow study visit schedule and contraception requirements.

Serious heart, lung, liver, or other medical problems that would make study treatment unsafe.
Active, uncontrolled infections.
Other active cancers that could interfere with study assessments (except certain early-stage cancers that have been treated).
Prior treatments or medicines that are not allowed by the protocol (for example, some strong drug interactions).
Known brain or nervous system involvement from the cancer that is not stable or controlled.
Pregnant or breastfeeding, or unwilling to use required birth control during and after the study.

First in Human Study of SNV1521 With a RAS Inhibitor for People With Advanced Pancreatic Cancer