Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem Brain Tissue Tau Pathology in Individuals With HV and MCI or AD.
1. Able to understand and voluntarily sign a written informed consent form (ICF).
2. Age≥50 years, male or female.
3. Charlson Comorbidity Index (CCI)≥5.
4. Able to tolerate imaging procedures.
5. For MCI or AD subjects: clinically diagnosed as AD-derived cognitive impairment or Alzheimer's dementia.
6. For HV subjects: no known personal or family history of AD-derived dementia.
You may not be if
1. Confirmed brain structural abnormalities that may affect PET reading, e.g., large stroke (infarct area\>4 cm) or intracranial space-occupying lesion.
2. Currently having clinically significant infectious diseases: HIV, hepatitis, etc.
3. Currently participating in any investigational clinical trial.
4. Previous participation in clinical studies of amyloid or tau-targeting agents.
5. Suspected hepatic encephalopathy.
6. Allergy to the investigational drug or any of its components.
7. Currently pregnant or breastfeeding.
8. Currently having a disease or condition that prolongs the QT interval.
