The three groups, each comprising 47 patients for a total of 141 patients, were randomly assigned and followed up in a 'double-blind' evaluation; they include patients meeting the following criteria Inclusion criteria are Both sexes, Unilateral knee prosthesis, Age \> 40 years Informed consent
Exclusion criteria are:
Severe medical conditions and coagulation disorders Lack of cooperation Absence of informed consent Unicompartmental and/or bilateral prostheses
Patients will be monitored for the first 3 days of their hospital stay, and will then be followed up by telephone at 30 days.
All data will be recorded in a dedicated case report form and subsequently analysed and evaluated
