Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
CONTACT
Lead
Hoffmann-La Roche
Age
18–85
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Ability and willingness to comply with all aspects of the protocol including completion of assessments for the duration of the study
Estimated Glomerular Filtration Rate (eGFR) calculated using the Body Surface Area (BSA)-adjusted Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
Participants with mild, moderate, or severe renal impairment/kidney failure and stable renal function
Participants with normal renal function matched to participants with renal impairment
You may not be if
Any condition or disease detected during the medical interview/physical examination that would render the participant unsuitable for the study, place the participant at undue risk, or interfere with the ability of the participant to complete the study in the opinion of the Investigator
History or evidence of any medical condition other than renal impairment capable of significantly altering the absorption, metabolism, or elimination of drugs
Surgical history of the gastrointestinal (GI) tract affecting gastric motility or altering the GI tract (with the exception of uncomplicated appendectomy and cholecystectomy)
History of malignancy in the past 5 years, except for fully treated local basal carcinoma, or fully treated carcinoma in situ of cervix
Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
History of cardiovascular, neurologic, psychiatric, or infectious disease
History of hypersensitivity to any of the excipients in Glucagon-like Peptide-1 (GLP-1) agonists
Bipolar disorder, schizophrenia, or any other serious psychiatric condition
Type 1 diabetes or poorly controlled Type 2 diabetes
Current or recent participation in another clinical study
Pregnancy or breastfeeding
Positive Human Immunodeficiency Virus (HIV), hepatitis B, hepatitis C, or tuberculosis test
History of alcohol or substance abuse
Clareo Health | A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions
