Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)

This is an early-stage clinical trial designed to test a new imaging drug called 203Pb-RMX-VH-PIB. The study will use SPECT/CT scans to see how the drug spreads through the body and how much radiation is delivered to different organs. The trial will enroll 20 patients who have either glioblastoma multiforme (GBM), an aggressive brain tumor, or pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer. Patients may be newly diagnosed, have recurrent disease, or have stable tumors. For GBM patients, the drug's distribution will be compared with MRI scans to see if it highlights the tumor areas effectively. For PDAC patients, the study will track how the drug behaves in pancreatic tumors. Participants will be divided into four groups to study both biodistribution and dosimetry in each cancer type. Each participant will receive a single intravenous injection of the drug, followed by several whole-body SPECT/CT scans. To ensure safety, vital signs will be measured before and after the injection, and blood and urine samples will be collected at multiple time points. A 12-lead ECG will also be performed to monitor heart rhythm, and results will be reviewed by the investigator. Any side effects or health changes will be closely monitored and recorded for 30 days after administration. The goal of this exploratory study is to better understand how 203Pb-RMXVH- PIB works in the body and to gather important safety and radiation data in patients with GBM and PDAC.