History of substance abuse or chronic opioid use.

Known allergies to acetaminophen, oxycodone, or suzetrigine.

Severe renal or hepatic dysfunction

Estimated glomerular filtration rate less than 15 ml/min/1.73m\^2

History of kidney transplant

Child-Pugh Class C

History of liver failure

Active hepatitis that can adversely influence hepatic function

Has had prior surgery on the study hand within the last 6 months

Is currently pregnant, planning to be pregnant, or breastfeeding

Use of strong or moderate CYP3A inhibitors or inducers, or medications known to interact with suzetrigine

Currently using a prescription pain medication other study medications

Journavx to Treat Pain After Thumb Basal Joint Arthroplasty