the study is asingle center observational study will be conducted at Assiut University Hospital,Internal medicine departement, ,Rheumatology and Renal unit(inpatient,\_outpatient clinics) including :Full history taking and thorough clinical examination including:
* Demographic Information: Collect data on age, gender, duration of illness, and relevant medical history.
* Body Mass Index (BMI)
* smoking status and Medications history as (corticosteroids, immunosuppressants and anti lipidemic drugs to be excluded)
* Clinical Assessment: patients diagnosed as SLE according to 2019 EULAR/ACR classification criteria. and lupus nephritis (LN) , classified according to the 2018 ISN/RPS classification of lupus nephritis.and Assessment of SLE disease activity according to SLEADI-2K score.
* Laboratory Tests:
* Combelete blood count (CBC)
* Lipid profile ( fasting TGS ,total cholesterol, LDL, HDL, VLDL)
* Fasting blood glucose (mg/Dl)
* Kidney function test (Serum Creatinine ,blood urea nitrogen)
* eGFR
* CRP
* Erthrocyte sedimentation rate (ESR)
* Autoantibody Profiles: ANA, anti-dsDNA
* Complement Levels: C3, C4
* Urinary protein excretion (24-hour urinary protein )
* Homocysteine
* Serum uric acid
* Renal biobsy
\- Indices calculation:
* Triglyceride-Glucose (TyG) Index
* The CRP\_TYG index \_- Carotid Ultrasonography
