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Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline

NCT07716722·1 site·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Pharmacology Translational Unit
CONTACT
937-245-7500 pturesearch@docdermgroup.com

Lead

Wright State University

Age

18–64

Sex

ALL

Healthy volunteers

Accepted

You may be eligible if

Adult Males/Females ages 18-64
All skin types on Fitzpatrick Scale (Type I-VI)
Able to comprehend procedures and risks
Must be able to give informed consent

You may not be if

Underlying diseases that could affect wound healing (e.g., uncontrolled diabetes mellitus)
History of abnormal scarring (i.e., keloids) or poor wound healing
No over the counter non-steroidal anti-inflammatory agents (aspirin, acetaminophen) or antioxidant vitamins (vitamin C) in past 14 days.
Currently taking known photosensitizers, anti-inflammatories, other tricyclic antidepressants, or systemic agents known to be ASM inhibitors
Large tattoos in designated testing areas
Tanning bed use within last 3 months
UVB treatments in past 3 months
Pregnant or nursing
Known allergies to lidocaine or amitriptyline

The record

StatusNot yet recruiting

PhasePhase 1

Taking part50

StartedOct 2026

UpdatedSep 30, 2026

Conditions

Thermal Burn Amitriptyline

Where1

Wright State University - Pharmacology Translational Unit
Fairborn, Ohio, United States