First line of the email MUST contain NCT # and Site #.
CONTACT
Lead
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Participants must be healthy male and female participants as determined by no clinically significant deviation from normal in medical history, physical examination, 12-lead ECG, VS, and clinical laboratory determinations.
Participants must be willing and able to be confined to an inpatient setting for a 3-week duration, follow instructions, and comply with the protocol requirements.
Participants must have BMI ≥ 18 and ≤ 40 kg/m2.
Individuals of childbearing potential (IOCBP) must be willing and able to adhere to the contraception guidelines.
You may not be if
Participants must not have history or presence of clinically significant cardiovascular (eg, untreated or unstable hypertension, clinically significant tachycardia), pulmonary, renal, hematologic, gastrointestinal (\[GI\] eg, obstructive disorders \[including conditions that may decrease GI motility, such as ulcerative colitis, intestinal atony, and myasthenia gravis\], active biliary disease \[including symptomatic gallstones\]), endocrine, immunologic, dermatologic, neurologic, or oncologic disease or any other condition that, in the opinion of the investigator, would jeopardize the safety of the participant or the validity of the study results.
Participants must not have history of moderate to severe alcohol use disorder or a substance (other than nicotine or caffeine) use disorder within the past 12 months or a positive urine drug screen (UDS) for a substance other than cannabis at screening or baseline.
Participants must not have history or high risk of urinary retention, gastric retention, or narrow-angle glaucoma.
Participants must not have active biliary disease (eg, symptomatic gallstones). Participants with other biliary histories are eligible and should be discussed with the medical monitor.
Clareo Health | Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers
