Two exercise modalities commonly used in pulmonary rehabilitation will be investigated independently in two sub-studies: (1) resistance training performed with BFR or without BFR, and (2) aerobic endurance training performed with BFR or without BFR.
Age
45–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Negative pregnancy test and use of an acceptable contraceptive method throughout the study duration for women of childbearing potential
Established COPD defined as obstructive ventilatory defect (FEV1/FVC \< 0.70 or below the 5th percentile)
Resting lung hyperinflation defined as functional residual capacity \> 2.5 z-scores according to the Global Lung Function Initiative (GLI)
Clinical stability of COPD for at least 3 months, with no recent exacerbation requiring treatment modification
Covered by a national health insurance system
Able and willing to provide written informed consent
Presence of a medical device incompatible with magnetic stimulation
Inability to perform an exercise test on a cycle ergometer
Any usual contraindication to exercise testing, including:
* Recent myocardial infarction (3-5 days)
* Unstable coronary insufficiency
* Severe stenotic valvular disease
* Uncontrolled arrhythmia with hemodynamic instability
Conditions contraindicating the use of blood flow restriction (BFR), including:
* Coagulation disorder
* Peripheral neuropathy
* Uncontrolled hypertension (\>160/100 mmHg)
* Peripheral arterial disease
* History of venous thrombosis
* Intensive care unit stay within the last 3 months
Participation in another study during an exclusion period
Inability to be contacted in case of emergency
Individuals covered under Articles L1121-5 to L1121-8 of the French Public Health Code (protected populations, including pregnant or breastfeeding women, prisoners, minors, individuals under legal protection, psychiatric inpatients, etc.)
Staff members with a hierarchical relationship with the principal investigator
