PRIMARY OBJECTIVE:
I. To describe overall symptom experience and quality of life (QOL) over time in breast cancer patients with brain metastases and/or leptomeningeal disease.
SECONDARY OBJECTIVES:
I. To evaluate the impact of cancer-directed treatments over time on quality of life, physical function, and cognitive function in patients with breast cancer brain metastases and/or leptomeningeal disease including:
* The impact of whole brain radiation versus stereotactic radiosurgery on QOL.
* The impact of brain metastasis surgical resection on QOL.
* The impact of CNS-penetrant systemic therapies on QOL.
* The impact of craniospinal irradiation and other treatment modalities for LMD on QOL.
EXPLORATORY OBJECTIVES:
I. To evaluate the interaction between QOL and demographics, social determinants of health, and control of systemic disease in patients with breast cancer brain metastases and/or leptomeningeal disease.
OUTLINE:
Participants will be given questionnaires and followed for at least 3 years but may withdraw at any time.
