Age

35–70

Sex

MALE

Healthy volunteers

Not accepted

\* Age 35-70 years
* Capable of providing informed consent
* Prognosis of \> 5 years if affected by another cancer
* Patients need one to meet at least one of the following high genetic risk categories:
* Known PCa-related mutations: BRCA 1 and 2, Lynch syndrome, or p53
* Carrier of mutation in a suspected PCa-related gene: e.g., ATM, PALB2, CHEK2, RAD51D, ATR, NBN, GEN1, RAD51C, MRE11A, BRIP1, FAM175A, HOXB13
* Obligate carriers of the above mutations (e.g. their sisters/daughters have known mutations)
* Men with any family history of above mutation
* Family history of breast, prostate, or ovarian cancer in at least 2 individuals, or in 1 individual diagnosed before age 50

Targeted Early Detection Program in Men at High Genetic Risk for Prostate Cancer