Discovering Determinants of Food Intake by Application of Artificial Intelligence to Complex, High-Dimensional Data

Exclusion Criteria

• •An individual who meets any of the following criteria will be excluded from participation in this study:
• •1. Weight \>=204 kg (\>=450 pounds, maximum weight of the iDXA machine as per manufacturer s manual), or weight \<45.4 kg (\<100 pounds, minimum weight allowed based on the NIH guidelines of blood drawing for research purposes)
• •2. Unstable weight (+/-5%) within past 6 months as determined by volunteer self-report.
• •3. Current use of medications, dietary supplements, or alternative therapies known to alter energy metabolism
• •4. Inability to consume provided food based on food allergy or intolerance or other food restrictions (e.g., kosher, vegan, or vegetarian)
• •5. Current pregnancy, or recent pregnancy within past 6 months or currently lactating
• •6. History or clinical manifestation of:
• •6i. Diabetes, including fasting glucose \>= 126 mg/dl or HbA1c \>= 6.5%, or history
• •6ii. Surgery for treatment of obesity
• •6iii. Endocrine disorders, such as Cushing s disease, pituitary disorders, or hypo- and hyperthyroidism (TSH \<0.1 or \>= 10 uIU/mL)
• •6iv. Pulmonary disorders including chronic obstructive pulmonary disease or other lung disease that which would limit ability to follow the protocol
• •6v. History of coronary artery disease, heart failure, arrhythmias, and peripheral artery disease that which would limit ability to follow the protocol
• •6vi. Liver disease, including cirrhosis, active hepatitis B or C based on history, and AST or ALT \>= 3x normal
• •6vii. Gastrointestinal disease including Crohn's disease, ulcerative colitis, celiac disease, or other malabsorptive disorders by history
• •6viii. Hematologic disorders including significant anemia (male hemoglobin \< 13.0 g/dL or female hemoglobin \< 11.0 g/dL)
• •6ix. Renal disease including abnormal kidney function (eGFR \<60 mL/min/1.73m\^2)Subjects page 4, Eligibility Criteria
• •6x. Central nervous system disease, including cerebrovascular accidents, dementia, and neurodegenerative disorders by history
• •6xi. Cancer requiring treatment in the past 5 years, except for nonmelanoma skin cancers or cancers that have clearly been cured
• •6xii. Infectious disease such as active tuberculosis, HIV (by self-report), chronic coccidiomycosis or other chronic infections that might influence appetite
• •6xiii. Diagnosis of binge eating disorder, anorexia, or major psychiatric disorders including depression, schizophrenia, and psychosis
• •6xiv. Menopausal transition (late) to early postmenopause (e.g., \>= 2 skipped cycles and an interval of amenorrhea \>= 60 days and \<12 months)
• •7\. Alcohol abuse as defined by \>= 8-point score on the Alcohol Use Disorders Identification Test (AUDIT) questionnaire interview
• •8\. Inability to provide informed consent
• •9\. Any disorder, unwillingness, or inability not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators, such as those that jeopardize the safety of the participant or others, or would interfere with completion of study procedures