Patients must be ≥ 18 years of age (or the legal age of consent in the jurisdiction in which the study is taking place), inclusive, at the time of signing the Informed consent form (ICF).
Patients must have a confirmed diagnosis of myeloid malignancies based on 2016 World Health Organization criteria, and meet the following categories:
* Relapsed/refractory; myeloid malignancies after ≥1 prior systemic therapy, per ELN; 2022 criteria; patients with actionable genetic alteration must have previously received targeted therapies unless contraindicated, unavailable/inaccessible, or declined by patient.
Patients must have a stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2.
You may not be if
Prior exposure to KAT6A/B inhibitors/degraders.
A diagnosis of acute promyelocytic leukemia or BCR-ABL-positive leukemia.
Known central nervous system involvement by leukemia
Use of antileukemic therapies without sufficient washout period
