diagnosis of non-responsive chronic migraine (NRCM) according to ICHD-3 beta criteria;
presence of at least 8 migraine days per month associated with disability (MIDAS ≥ 11), and insufficient response after 6 weeks or inability to tolerate at least three previously prescribed migraine preventive agents, i.e., resistance to standard therapy for at least 6 weeks;
signed informed consent.
adults aged ≥ 18 years and not older than 75 years;
absence of a diagnosis of NRCM according to ICHD3beta or other relevant -neurological disorders as assessed during the medical history taken at the headache center;
signed informed consent.
You may not be if
older than 75 years;
children
pregnant or breastfeeding women;
history of alcohol or substance abuse;
affected by concomitant neurological, cardiovascular, or cerebrovascular diseases;
liver disease or kidney disease;
psychiatric disorders (psychosis, major depression, bipolar disorder).
diagnosis or history of migraine (for healthy subjects).
Clareo Health | The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine
