1. Female patients with a diagnosis of multiple sclerosis
2. Age \> 18
3. Moderate to severe lower urinary tract symptoms as defined by an AUASS score \> 8
4. No UTI
You may not be if
1. Treatment with alpha-blocker, B3 agonist, or anticholinergic medication within the last 6 weeks
2. Treatment with sacral neuromodulation, bladder Botox, or posterior tibial nerve stimulation within the last 9 months
3. Renal impairment with CrCl \< 30
4. PVR \> 300
5. Diagnosed orthostatic hypotension
6. Pregnancy or breastfeeding
7. Severe liver impairment (Child-Pugh class C)
8. Current symptomatic kidney stones
9. Recent MS relapse within the last 3 months
10. Recent treatment with steroids in the last 3 months (this does not include one-time pre-treatment with steroids for administration of immunologic drug)
Clareo Health | Silodosin for Urinary Symptoms in Female Patients With Multiple Sclerosis
