Diansan SU, Cheif of Anesthesiology Department, PhD

CONTACT

Shuying Fu

CONTACT

Lead Sponsor

Zhejiang University

Age

18 - 80 years

Sex

MALE

Healthy Volunteers

No

•1. Aged 18 to 80 years old (inclusive);
•2. American Society of Anesthesiologists (ASA) physical status classification Class I-III;
•3. Undergoing elective laparoscopic radical prostatectomy under general anesthesia;
•4. Having a clear understanding of the study, voluntarily participating, and providing informed consent signed by themselves or their family members.

•1. Pre-existing bladder diseases, such as overactive bladder (frequency of micturition \> 3 times per night or \> 8 times within 24 hours), neurogenic bladder, and bladder outlet obstruction;
•2. Postoperative status of pelvic organs or spine that affects bladder function;
•3. Postoperative status of total proctocolectomy;
•4. Severe cardiac insufficiency (activity tolerance \< 4 METs) or clearly diagnosed coronary heart disease;
•5. Clearly diagnosed chronic obstructive pulmonary disease (COPD) or a history of asthma;
•6. Hepatic insufficiency with Child-Pugh Class C;
•7. Chronic kidney disease requiring dialysis;
•8. Active peptic ulcer/hemorrhagic disease;
•9. Body mass index (BMI) ≤ 18 kg/m² or ≥ 28 kg/m²;
•10. Chronic analgesic abuse;
•11. Use of other nonsteroidal anti-inflammatory drugs (NSAIDs) within one week;
•12. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs);
•13. Mental or neurological disorders that prevent the completion of rating scales; or cognitive impairment resulting in the loss of capacity for civil conduct.