Histologically confirmed cancer with evidence of advanced disease for which no other standard treatment is available
ECOG Performance status of 0 to 2
Adequate hematological, renal, and hepatic organ function
You may not be if
Previous systemic treatment with TLR agonists, with the exception of TLR agonists used as vaccine adjuvants.
Known additional malignancy that is progressing or requires active treatment
Diagnosis of immunodeficiency
Active autoimmune disease not caused by prior anticancer treatment that required systemic immunosuppressive treatment in the past 2 years
Active autoimmune disease caused by prior anticancer treatment, unless currently controlled by replacement therapy only.
Any kind of leukemia
Previously received an organ transplant (other than corneal transplants) or hematopoietic stem cell transplantation
Known active central nervous system metastases and/or carcinomatous meningitis
Cerebral vascular event within 6 months before Screening
Unstable cardiopulmonary status defined by uncontrolled congestive heart failure of New York Heart Association Grade III or IV, unstable angina, or myocardial infarction within 6 months before Screening
High grade ocular disease such as uncontrolled glaucoma
Clareo Health | A First-in-Human Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of KUP-101A in Patients With Selected Advanced Solid Tumors
