Abemaciclib Dose Escalation in Early High-Risk Breast Cancer Adjuvant Therapy

Exclusion Criteria

• •Previous exposure to any CDK4/6 inhibitor;
• •Active infection or severe infection requiring systemic anti-infective treatment;
• •Significant gastrointestinal diseases such as chronic diarrhea, inflammatory bowel disease, short bowel syndrome, which may affect drug absorption or increase the risk of diarrhea;
• •Significant baseline hepatic or renal dysfunction, or uncontrolled severe comorbidities judged by the investigator to affect safety or treatment adherence;
• •Pregnancy or lactation;
• •Any other condition deemed ineligible for enrollment by the investigator.