Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes Mellitus

Exclusion Criteria

• •Participation in another clinical trial;
• •Pregnancy or lactation;
• •Smoker;
• •Individuals with autoimmune diseases;
• •Individuals with compromized medical conditions requiring prophylactic antibiotic therapy (e.g., patients with valvular prosthesis, patients with history of infective endocarditis, heart transplant recipients, etc.);
• •Individuals currently receiving ongoing drug therapy (corticosteroid, bisphosphonates, nonsteroidal anti-inflammatory drugs, etc.);
• •Use of systemic antibiotics within the 3 months prior to the study;
• •Use of probiotic products within the 3 months prior to the study;
• •History of subgingival instrumentation within the previous 6 months;
• •Presence of acute periodontal lesions and/or endo-periodontal lesions (Herrera et al., 2018);
• •Physical limitations that may interfere proper oral hygiene practices.