Liposomal Irinotecan Plus Enlonstobart for Platinum-Resistant Recurrent Ovarian Cancer

Ovarian cancer is one of the most common gynecologic malignancies and has the highest mortality among gynecologic cancers. Most patients are diagnosed at an advanced stage, and recurrence is common after standard surgery and platinum-taxane-based chemotherapy. For patients with platinum-resistant recurrent ovarian cancer, treatment options remain limited and new therapeutic strategies are needed. Irinotecan is a topoisomerase I inhibitor with antitumor activity in ovarian cancer. Liposomal irinotecan is a liposomal formulation designed to prolong circulation time, increase tumor drug accumulation, and reduce systemic toxicity compared with conventional irinotecan. Immune checkpoint inhibitors have shown activity in selected tumor types, and preclinical and clinical evidence suggests that irinotecan may enhance the effect of anti-PD-1 therapy. Enlonstobart is an anti-PD-1 monoclonal antibody. This exploratory study will evaluate the objective response rate, progression-free survival, overall survival, and safety of liposomal irinotecan combined with enlonstobart in patients with platinum-resistant recurrent ovarian cancer receiving second- to fourth-line treatment.