Anesthesia Type and HoLEP Outcomes: A Multi-Center Study

Benign prostatic obstruction (BPO) is the leading cause of lower urinary tract symptoms (LUTS) among men older than 40 years. Surgery is recommended under circumstances such as: * Bothersome LUTS resistant to medical treatment. * Acute kidney injury, bladder stone(s), resistant hematuria and urinary retention. * Preference of the patient. Various surgical methods exist to treat BPO, but the most appropriate choice depends on the operator and the patient. HoLEP is an abbreviation for holmium laser enucleation of prostate, which is one of the endoscopic laser enucleation techniques. Both spinal and general anesthesia are applicable for HoLEP surgery. The type of anesthesia is determined by the anesthesiologist, independently of the operator's preference, taking into account several factors related to the patient, such as safety and comfort. Controlled bleeding is one of the expected outcomes in HoLEP, and several factors determine the amount of bleeding. For HoLEP, the type of anesthesia may be one of them, as other studies have claimed. This multicenter, prospective observational study may further reveal the impact of anesthesia type on bleeding. The amount of bleeding could be "less or more", determined according to the content below: * Amount of hemoglobin and hematocrit decreased, measured by laboratory examinations, preoperatively, during, and on the day after the surgery. * Vital changes such as hypotension, tachycardia, that require blood transfusion due to "more" bleeding during either the surgery or hospital stay after surgery. * Usually, a shorter duration of bladder irrigation to clean blood in the urine during hospital stay after the surgery is required for "less" bleeding. Participants who are eligible and willing to provide informed consent will undergo HoLEP. Preoperative, perioperative, and postoperative data will be collected without disclosing the participant or any personal data relating to the participant. Participants will be grouped into two groups based on anesthesia type: general or spinal. To answer the main question of this study, a power analysis was conducted, concluding that at least 320 participants are required (intention-to-treat population). All collected data will be recorded and analyzed according to the proper statistical methods. Results will be reported.