A Prospective Observational Cohort Study Protocol for Disease Severity Stratification and Prognosis Assessment in Patients With Pneumonia

Inclusion Criteria

• •Main Criteria:
• •① Requires mechanical ventilation with tracheal intubation
• •② Requires vasopressor drugs after aggressive fluid resuscitation for septic shock
• •Secondary Criteria:
• •* Respiratory rate ≥ 30 breaths/min
• •* PaO₂/FiO₂ ≤ 250 mm Hg
• •* Multiple lobe infiltrates
• •* Confusion and/or disorientation
• •⑤ Blood urea nitrogen ≥ 20 mg/dL
• •⑥ Leukopenia (WBC \< 4×10⁹/L)
• •⑦ Thrombocytopenia (PLT \< 100×10⁹/L)
• •⑧ Decreased body temperature (central body temperature \< 36 ℃)
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• •1. Age ≥ 18 years old;
• •2. Having infection-related symptoms or signs (such as fever, cough, sputum production, elevated white blood cells, etc.), clinically suspected of pneumonia;
• •3. All pathogen tests are negative within 3 days after admission;
• •4. Time from onset to admission ≤ 72 hours;