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Clareo Health | Prevention of AIDS With Opportunistic Infection Paradoxical IRIS

Prevention of AIDS With Opportunistic Infection Paradoxical IRIS

NCT07565623·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

jia tang, MD
CONTACT
18974693450 tangsweetness@163.com

Lead

Shanghai Public Health Clinical Center

With

Beijing Ditan Hospital
Meng Chao Hepatobiliary Hospital of Fujian Medical University
Chengdu Public Health Clinical Center
The Third Affiliated Hospital of Kunming Medical College.
Chongqing Public Health Medical Center
The Second Hospital of Nanjing Medical University
First Affiliated Hospital of Zhejiang University
Peking Union Medical College Hospital

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Age ≥ 18 years;
Confirmed HIV infection;
Presence of HIV-related opportunistic infection(s), including non-tuberculous -mycobacterial infection, PJP, pneumonia, cryptococcal meningitis, Talaromyces marneffei infection, CMV retinitis, or PML;
Baseline CD4 T-lymphocyte count \< 100 cells/μL;
Planned initiation of antiretroviral therapy;
Willing to participate in this study, able to comply with all follow-up requirements, and able to provide written informed consent.

You may not be if

Presence of Kaposi sarcoma, pregnancy, or confirmed tuberculosis;
Body weight \< 40 kg;
Severe hepatic dysfunction (ALT or AST \> 5 times the upper limit of normal, ULN);
Severe renal dysfunction (eGFR \< 30 mL/min/1.73 m²);
Baseline electrocardiogram (ECG) showing a QTc interval \> 500 ms;
Pregnant or lactating women;
Contraindications to glucocorticoid use;
Any other condition considered by the investigators to be unsuitable for participation in this study.

The record

StatusNot yet recruiting

PhaseNo phase

Taking part131

StartedMay 2026

UpdatedMay 4, 2026

Conditions

HIV (Human Immunodeficiency Virus)IRIS