Phase II Study Of Nivolumab Plus AVD In Pediatric, Adolescent, And Young Adult Patients With CHL

Primary Objectives: Patients receive nivolumab intravenously (IV) over 30 minutes, doxorubicin IV over 15 minutes, vinblastine IV over 15 minutes, and dacarbazine IV over 60 minutes on days 1 and 15 of each cycle. I. To characterize the clinical preliminary efficacy of nivolumab plus AVD in pediatric, adolescent, and young adult patients with newly diagnosed early-stage non-bulky classical Hodgkin lymphoma based upon the overall response rate (ORR). II. To assess the safety of nivolumab plus AVD in pediatric, adolescent, and young adult patients with newly diagnosed early-stage non-bulky classical Hodgkin lymphoma. III. To summarize the incidence, prevalence, and severity of adverse drug reactions according to Common Terminology Criteria for Adverse Events (CTCAE) National Cancer Institute (NCI) CTCAE version 5.0. Secondary Objective: I. To assess the efficacy and duration of response (DOR), relapse-free survival (RFS), and overall survival (OS) of patients with newly diagnosed early-stage non-bulky classical Hodgkin lymphoma treated with this combination. Outline: Patients receive nivolumab intravenously (IV) over 30 minutes, doxorubicin IV over 15 minutes, vinblastine IV over 15 minutes, and dacarbazine IV over 60 minutes on days 1 and 15 of each cycle. Cycles repeat every 28 days for 2 cycles. After cycle 2, patients with complete response and Deauville score of 1, 2, or 3 receive 2 additional cycles of treatment (cycles 3 and 4). Patients with partial response or stable disease (Deauville score of 4 or 5) receive 4 additional cycles of treatment (cycles 3-6). Patient with progressive disease, no response, or unacceptable toxicity will come off study.