Verification of Range Accuracy and Correlation With Clinical Toxicity Using Offline PET/CT for Hypofractionated Proton Radiotherapy in Breast Cancer

Inclusion Criteria

• •1. Written informed consent obtained.
• •2. Female aged ≥18 years.
• •3. Pathologically confirmed breast cancer after curative surgery (breast-conserving or mastectomy) and indicated for postoperative adjuvant radiotherapy.
• •4. Scheduled to receive moderate or ultra-hypofractionated proton therapy.
• •5. KPS ≥80, expected survival \>5 years.
• •6. Well-healed surgical incision without infection.
• •7. Fertile females must use contraception for ≥1 month before screening and throughout the study.