MCE Molecular Imaging for ICI Myocarditis

Inclusion Criteria

• •Age ≥18 years of age
• •Treatment with single or combination ICI therapy targeted to CTLA-4, PD-1, or PD-L1 with an ICI within the past week
• •At least two of the following manifestations of ICI myocarditis:
• •1. new or suspected new high-sensitivity troponin \>3 times upper limit of normal
• •2. new or suspected new LV dysfunction with LVEF \<50% or any segmental wall motion abnormality in the absence of prior ischemic event
• •3. ECG changes consistent with myocarditis defined as either diffuse ST elevation or ST-T abnormalities that are documented to be new,
• •4. unexplained severe ventricular arrhythmias,
• •5. Cardiac MR evidence for myocarditis