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Not Yet RecruitingNCT07529964

MMP-2/3 and Periapical Healing Outcomes

This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in p...

Lead sponsor: TC Erciyes University•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

TC Erciyes University

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Single-rooted teeth
•PAI score ≥ 3
•Fully developed root apices
•Periodontal probing depth less than 5 mm
•Indication for primary nonsurgical root canal treatment

Exclusion Criteria

•Previous endodontic treatment in the selected tooth
•Diagnosis of symptomatic apical abscess
•Presence of root fracture or internal/external resorption
•Use of systemic antibiotics within the previous 4 weeks
•Analgesic intake within 48 hours before treatment
•Ongoing immunosuppressive therapy
•Pregnancy or breastfeeding

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 14, 2026Terms

Trial snapshot

StatusNOT_YET_RECRUITING

Phase—

Enrollment50

Start dateMay 2026

Last updatedApr 14, 2026

Condition

Chronic Apical Periodontitis Periapical Healing

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 14, 2026Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions