First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis

Exclusion Criteria

• •Part A:
• •1. Hospitalized (\>24 hours) for any reason within 30 days prior to the screening visit
• •2. Hypersensitivity to the study treatment or any of its excipients
• •3. History of clinical parasite infection, except treated trichomoniasis
• •4. Received a live attenuated vaccine within 1 month prior to the first screening visit or anticipates need for a live attenuated vaccine during the study
• •5. History of alcohol or drug abuse as determined by the investigator
• •Part B:
• •6. Known or suspected history of immunosuppression
• •7. Presence of skin comorbidities at screening that may interfere with study assessments
• •8. Inability to discontinue medications and treatments prior to baseline and during the study per the Excluded Medications and Treatments list
• •9. Uncontrolled chronic disease that might require bursts of oral corticosteroids during the study