Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Eloxx Pharmaceuticals, Inc.
Age
12–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
A confirmed diagnosis of X-linked or autosomal recessive Alport Syndrome with a documented nonsense mutation of COL4A5 in a male or nonsense mutation of COL4A3 or COL4A4 (male or female)
eGFR\>40 ml/min/1.73 m2
Urinary protein based on two spot urine collections \[urine protein/creatinine ratio (UPCR) ≥ 300 mg/g\]
Stable regimen of ACEi/ARB for at least 12 weeks before Day 1
You may not be if
History of any organ transplantation
Liver disease characterized by cirrhosis or portal hypertension. Participants with alanine aminotransferase (ALT), aspartate aminotransferase (AST), and/or a total bilirubin 1.5 times the upper limit of normal (ULN) will be excluded
History of dialysis
Acute kidney injury within 4 weeks before screening
Active dizziness
Clareo Health | EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety
