The HIt HArd and hiT Early in Multiple Sclerosis Trial

Exclusion Criteria

• •Diagnosis of progressive MS,
• •Previous use of rituximab (or any other B-cell depleting monoclonal antibody) and/or cladribine,
• •Pregnant or lactating women,
• •Unwilling to use contraception during the treatment period and the first year after completing the treatment course,
• •Patients having contraindication for or otherwise not compliant with MRI investigations,
• •Simultaneous treatment with other immunosuppressive drugs,
• •Infection with human immunodeficiency virus (HIV),
• •Active, severe infections (e.g. hepatitis or tuberculosis),
• •Severe cardiac disorder,
• •Moderate or severe renal impairment (eGFR \<60).
• •Active malignancy,
• •No prior exposure to varicella virus,
• •Vaccination within 4 weeks of first dose of study medication,
• •Severe psychiatric condition.