Diagnosis of RRMS according to the 2017 revised McDonald criteria,
With disease activity within the preceding year in the form of: a clinical relapse, and/or evidence of ≥2 T2 lesions on MRI scan, and or presence of gadolinium enhancing lesions on an MRI scan,
Age 18 - 50 years (inclusive) of age,
Disease duration ≤10 years (since MS diagnosis),
EDSS 0 - 5.5 (inclusive),
Signed informed consent.
You may not be if
Diagnosis of progressive MS,
Previous use of rituximab (or any other B-cell depleting monoclonal antibody) and/or cladribine,
Pregnant or lactating women,
Unwilling to use contraception during the treatment period and the first year after completing the treatment course,
Patients having contraindication for or otherwise not compliant with MRI investigations,
Simultaneous treatment with other immunosuppressive drugs,
Infection with human immunodeficiency virus (HIV),
Active, severe infections (e.g. hepatitis or tuberculosis),
Severe cardiac disorder,
Moderate or severe renal impairment (eGFR \<60).
Active malignancy,
No prior exposure to varicella virus,
Vaccination within 4 weeks of first dose of study medication,
Severe psychiatric condition.
Clareo Health | The HIt HArd and hiT Early in Multiple Sclerosis Trial
