Neuroprotection of Memantine and Rosuvastatin

Exclusion Criteria

• •Children \< 18 years old.
• •Prior exposure to neurotoxic chemotherapy (oxaliplatin, cisplatin, vincristine, paclitaxel, or docetaxel, INH).
• •Patients with diabetes and other conditions that predispose to neuropathy as hypothyroidism, autoimmune diseases, hepatitis C.
• •History of known allergy to oxaliplatin or other platinum agents.
• •Patients with other inflammatory or stressful conditions.
• •Concomitant use of multivitamins (vitamins E, C, A), tricyclic antidepressants, other neuro-protective medications (gabapentin, lamotrigine, carbamazepine and phenytoin).
• •Patients on amantadine , acetazolamide, dextromethorphan, aluminum hydroxide magnesium hydroxide and febuxostat .
• •Concurrent active cancer originating from a primary site other than colon or rectum.
• •Pregnant and breastfeeding women.
• •Sever renal insufficiency (creatinine clearance \< 25 ml/ minute) .