BRAHMS: Bed Rest And HypoMetabolism Study

Exclusion Criteria

• •Any history or presence of clinically relevant chronic disease; any acute infectious disease. Particularly (but not limited to):
• •Symptomatic orthostatic hypotension whatever the decrease in blood pressure, or asymptomatic postural hypotension defined by a decrease in SBP equal to or greater than 20 mmHg within 3 minutes when changing from the supine to the standing position
• •Personal or family history of thrombosis, genetic mutation for factor V or prothrombin gene
• •Cardiac arrhythmia
• •Hypertension
• •Auto-immune diseases or Raynaud's syndrome
• •History or symptoms of sleep apnea
• •Chronic back pains,
• •Vertebral fracture, scoliosis, or herniated disc,
• •Color-blindness,
• •Self-reported hearing problems or binocular visual acuity under 6/10 after correction
• •Vestibular disorders
• •Drug addiction
• •History of migraines,
• •History of hiatus hernia or gastro-esophageal reflux,
• •History of thyroid dysfunction or diabetes
• •History of head trauma,
• •History of neurological diseases (e.g. epilepsy)
• •History of genetic muscle and bone diseases of any kind
• •Significant history of allergies
• •Significant abnormality in blood tests
• •Positive serology for hepatitis A, hepatitis B, hepatitis C or AIDS (HIV) virus
• •Mood and Eating disorder (current or past), screened with the Hospital Anxiety Depression Scale (HADS), SCOFF (Sick, Control, One, Fat, Food) and the Eating Disorder Examination Questionnaire (EDE-Q)
• •Antibiotics exposure 2 months prior to the study
• •Major lifestyle changes (e.g. significant weight/body changes, diet or exercises regimen) 6 months prior to the study
• •Specific diet (e.g vegan, carnivore, intermittent fasting, dietary supplements consumption)
• •History of hypocaloric diet, judged as significant by the investigator
• •Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development,
• •Subject in the exclusion period of another clinical research,
• •Subject who received 6000 Euros or more within 12 months for being a research subject,
• •Poor tolerance to blood sampling,
• •Subject who cannot be contacted in case of emergency,
• •Contraindications for MRI: claustrophobia, presence of osteosynthesis material or metal implants,
• •Blood donation of more than 7 ml/kg in the 8 weeks prior to the start of the study,
• •Vulnerable people according to law "Code de la Santé Publique" (L1121-5 to L1121-8):
• •Pregnant or nursing women (urine pregnancy test for women of childbearing potential)
• •People deprived of their liberty by an administrative or judicial decision
• •People under involuntary psychiatric care
• •People admitted in a health or social establishment for purposes other than research
• •Minors
• •Adults subject to legal protection (subject under guardianship or trusteeship) or unable to express their consent