Defining Objective Markers of Compliance for Dietary Therapies in IBS

Exclusion Criteria

• •1. Subjects adhering to a dietary treatment such as the low-fat diet, low FODMAP diet, or gluten-free diet, within the past 6 months. Those who are lactose intolerant will not be excluded from the study and will be allowed to limit lactose intake as previously.
• •2. Subjects who are predicted to make changes to their baseline IBS medication(s), over-the-counter (OTC) therapy, exercise, diet (beyond what is advised), or initiate/make changes to other complementary therapy that could affect IBS symptoms (e.g. yoga, acupuncture, etc.) during the four weeks study period.
• •3. Subjects with a known history of celiac disease, inflammatory bowel disease or microscopic colitis
• •4. Subjects with a history of an eating disorder requiring medical or behavioral treatment within the past 10 years.
• •5. BMI \< 18.5
• •6. Subjects with prior small bowel or colonic surgery (other than appendectomy or cholecystectomy).
• •7. History of appendectomy or cholecystectomy in the last 6 months.
• •8. Oral antibiotic use in the past 3 months
• •9. Any planned significant changes in dietary or exercise regimen within 30 days prior to Screening or during the study.
• •10. Currently pregnant or breastfeeding.