Efficacy and Safety of Telitacicept Combined With Baricitinib for Refractory Rheumatoid Arthritis

Exclusion Criteria

• •1\. Exclusion of patients with severe diseases of major organs (e.g., heart, liver, or lungs)
• •2\. Patients with malignancies, hematological disorders, or other autoimmune diseases (excluding rheumatoid arthritis)
• •3\. History of allergy/hypersensitivity to the study medications (Telitacicept or Tofacitinib)
• •4\. Active tuberculosis or active infectious diseases requiring systemic treatment
• •5\. Pregnancy, lactation, or refusal to use contraception during the study
• •6\. Failure to complete the prescribed Telitacicept + Tofacitinib regimen due
• •to:Non-adherence or Severe adverse reactions
• •7\. Other conditions contraindicating participation per investigator judgment