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Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction

The Effect of Repetitive Transcranial Magnetic Stimulation on Cardiac Autonomic Dysfunction in Patients With Stroke

NCT07482501•Afyonkarahisar Health Sciences University

Summary

The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke.

Detailed Description

Stroke is a leading cause of disability worldwide and is frequently associated with autonomic dysfunction (AD). AD can affect heart function, arterial blood pressure, fluid balance, and other body systems, negatively influencing clinical outcomes and prognosis. Brain damage in cortical and subcortical regions during stroke can disrupt the integrity of the central autonomic network, leading to AD. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method thought to support neuroplasticity and potentially improve autonomic function. This study aims to investigate the effects of rTMS on autonomic dysfunction and related functional parameters in patients with stroke.

Eligibility

Age

35 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Participants aged 35-80 years admitted to the Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Unit for neurological rehabilitation after stroke
•Participants with a history of stroke of at least 3 months
•Neurologically and medically stable participants willing to participate regularly in the study
•Participants capable of following commands

Exclusion Criteria

•Serious cardiac disease, uncontrolled hypertension
•Epilepsy or history of antiepileptic drug use
•Intracranial metallic implants
•Inner ear implants
•Malignancy
•Active infection
•Skin infection or open wound in the intervention area
•Brain lesions or medications that may alter the seizure threshold
•Increased intracranial pressure
•Uncontrolled migraine
+2 more criteria

Locations (1)

Afyonkarahisar Health Science University

Afyonkarahisar, Turkey (Türkiye)

Key Dates

Start Date

March 23, 2026

Primary Completion Date

June 15, 2026

Completion Date

September 15, 2026

Last Updated

March 20, 2026

Enrollment

ESTIMATED participants

Conditions

StrokeAutonomic DysfunctionHemiparesis

Interventions

rTMS M1 Motor Cortex Protocol

DEVICE

Sham rTMS Protocol

DEVICE

Contacts

ülkü demir

CONTACT

5423541114 ulkudemir_44@hotmail.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction

Inclusion Criteria

Exclusion Criteria

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