Safety and Immunogenicity of CVI-VZV-001 in Adults Aged 50 Years and Above

Exclusion Criteria

• •Participants meeting any of the following criteria will be excluded:
• •* History of herpes zoster prior to screening
• •* History of severe allergic reaction to vaccines or vaccine components
• •* Known immunodeficiency or immune dysfunction
• •* Prior vaccination with varicella or herpes zoster vaccine
• •* Use of immunosuppressive therapy or systemic steroids that may affect immune response
• •* Positive test for HCV, HBV, or HIV at screening
• •* Pregnant or breastfeeding women
• •* Any medical condition that, in the opinion of the investigator, would make participation unsafe or interfere with study evaluation