Lead Sponsor

University of Nebraska

Age

19 - 50 years

Sex

MALE

Healthy Volunteers

No

•Male participants aged 19 to 50 years
•Confirmed diagnosis of oligospermia (sperm concentration \<15 million/mL), nonobstructive azoospermia, or hypogonadotropic hypogonadism (defined by low or normal FSH with low testosterone)
•Normal genetic evaluation if diagnosed with azoospermia
•No other identified and correctable cause of infertility
•Considered appropriate candidates for medical therapy for infertility in the clinical judgment of the investigators
•Willing and able to comply with study procedures, including laboratory testing, semen analyses, and follow-up visits
•Able to provide informed consent

•Obstructive azoospermia (including vasal obstruction, ejaculatory duct obstruction, or prior vasectomy)
•Prior successful medical therapy for infertility
•Current or recent use of medications known to impair spermatogenesis, including exogenous testosterone or anabolic steroids, unless discontinued with adequate washout
•Current use of isotretinoin for any indication
•Contraindications to isotretinoin (including significant liver disease or uncontrolled hyperlipidemia)
•Contraindications to human chorionic gonadotropin (including hormone-sensitive malignancy)
•Significant medical or psychiatric conditions that, in the opinion of the investigators, would interfere with safe participation
•Inability to provide semen samples
•Inability to provide informed consent