Adaptation of Lung Transplant Recipients at Extreme Altitude

Inclusion Criteria

• •Lung transplant recipients:
• •Age ≥ 18 years
• •\> 1 years after lung transplantation
• •Stable lung function over 6 month prior to inclusion, FEV1 +/-10% from baseline
• •VO2peak of more than 25 ml/min/kg
• •Physical and mental fitness, defined as the ability to complete strenuous day trips lasting 8 to 10 hours independently without suffering from a fear of heights, an altitude exposure of at least 2500m must be confirmed.
• •Negative pregnancy test for women of childbearing age
• •Written informed consent
• •Healthy volunteers:
• •Age ≥ 18 years
• •VO2peak of more than 25 ml/min/kg
• •Physical and mental fitness, defined as the ability to complete strenuous day trips lasting 8 to 10 hours independently without suffering from a fear of heights
• •Negative pregnancy test for women of childbearing age
• •Written informed consent